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If you take Atorvastatin with certain other medicines, they may affect one another. Atorvastatin may interact with certain other cholesterol-lowering drugs, some antibiotics, and antifungal medications. It may also interact with less-frequently prescribed medications as immunosuppressives (given after transplants). Be sure to tell your doctor or pharmacist about all prescription and nonprescription drugs you are taking. How long does it take Atorvastatin to work? Atorvastatin works by blocking an enzyme in the liver that your body uses to make cholesterol. When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream. This results in lower levels of cholesterol circulating in your blood. Atorvastatin works by blocking an enzyme in the liver that your body uses to make cholesterol. When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream. This results in lower levels of cholesterol circulating in your blood. Atorvastatin is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children. If you think this is written by another internet crackpot, take a look at Dr. Ravnskov's credentials and the reviews of his book. For information about taking Atorvastatin along with other medicines, see your doctor or pharmacist. If you experience side effects, be sure to tell your doctor or other healthcare professional.