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If you take Atorvastatin with certain other medicines, they may affect one another. Atorvastatin may interact with certain other cholesterol-lowering drugs, some antibiotics, and antifungal medications. It may also interact with less-frequently prescribed medications as immunosuppressives (given after transplants). Be sure to tell your doctor or pharmacist about all prescription and nonprescription drugs you are taking. For information about taking Atorvastatin along with other medicines, see your doctor or pharmacist. If you experience side effects, be sure to tell your doctor or other healthcare professional. If you take Atorvastatin with certain other medicines, they may affect one another. Atorvastatin may interact with certain other cholesterol-lowering drugs, some antibiotics, and antifungal medications. It may also interact with less-frequently prescribed medications as immunosuppressives (given after transplants). Be sure to tell your doctor or pharmacist about all prescription and nonprescription drugs you are taking. What are the effects of Atorvastatin tablets? How long does it take Atorvastatin to work? In medical studies of people with high cholesterol, Atorvastatin, taken once a day, had the following effects at doses of 10 to 80 mg: Lowered total cholesterol by 29-45%. Lowered LDL cholesterol, the "bad" cholesterol, by 39-60%. Increased HDL cholesterol, the "good" cholesterol, by 5-9%. Lowered triglyceride levels by 19-37%. What is Atorvastatin? The International Network of Cholesterol Skeptic Here are the facts! Click on the blue arrows if you want the scientific evidence! A high blood cholesterol is said to promote atherosclerosis and thus also coronary heart disease. But many studies have shown that people whose blood cholesterol is low become just as atherosclerotic as people whose cholesterol is high. A high blood cholesterol is said to promote atherosclerosis and thus also coronary heart disease. But many studies have shown that people whose blood cholesterol is low become just as atherosclerotic as people whose cholesterol is high. Atorvastatin is a very effective medicine for lowering high LDL cholesterol—the main target of cholesterol-lowering therapy. Your doctor will determine how much your LDL cholesterol needs to be lowered, based on your overall risk of heart disease. Atorvastatin also effectively lowers high blood-triglyceride levels. Most people will require the starting dose, which is a 10 mg tablet once daily. Your doctor will prescribe the dose that is right for you, which may be 10 mg to 80 mg. Atorvastatin can be taken any time of the day, with or without food. To make it easier to remember to take Atorvastatin you can plan to take it at the same time each day, such as after you brush your teeth in the evening. The amount or how often Atorvastatin is taken should never be changed without consulting your healthcare professional. Most people will require the starting dose, which is a 10 mg tablet once daily. Your doctor will prescribe the dose that is right for you, which may be 10 mg to 80 mg. Atorvastatin can be taken any time of the day, with or without food. To make it easier to remember to take Atorvastatin you can plan to take it at the same time each day, such as after you brush your teeth in the evening. The amount or how often Atorvastatin is taken should never be changed without consulting your healthcare professional.