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How does Atorvastatin improve the different types of cholesterol? In medical studies of people with high cholesterol, Atorvastatin, taken once a day, had the following effects at doses of 10 to 80 mg: Lowered total cholesterol by 29-45%. Lowered LDL cholesterol, the "bad" cholesterol, by 39-60%. Increased HDL cholesterol, the "good" cholesterol, by 5-9%. Lowered triglyceride levels by 19-37%. For information about taking Atorvastatin along with other medicines, see your doctor or pharmacist. If you experience side effects, be sure to tell your doctor or other healthcare professional. Atorvastatin is generally well tolerated and side effects are usually mild. In studies, the most common side effects associated with Atorvastatin were constipation, flatulence, indigestion, and abdominal pain. If you are prescribed Atorvastatin, your healthcare professional may want to conduct routine blood tests to check your liver function before and after starting treatment. Be sure to tell your healthcare professional if you have any allergies to food or medication. Also, report promptly any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by discomfort or fever, as these symptoms may be signs of serious side effects. In medical studies of people with high cholesterol, Atorvastatin, taken once a day, had the following effects at doses of 10 to 80 mg: Lowered total cholesterol by 29-45%. Lowered LDL cholesterol, the "bad" cholesterol, by 39-60%. Increased HDL cholesterol, the "good" cholesterol, by 5-9%. Lowered triglyceride levels by 19-37%. What is Atorvastatin? Atorvastatin works by blocking an enzyme in the liver that your body uses to make cholesterol. When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream. This results in lower levels of cholesterol circulating in your blood. Atorvastatin works by blocking an enzyme in the liver that your body uses to make cholesterol. When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream. This results in lower levels of cholesterol circulating in your blood. A high blood cholesterol is said to promote atherosclerosis and thus also coronary heart disease. But many studies have shown that people whose blood cholesterol is low become just as atherosclerotic as people whose cholesterol is high.